Cycladol PS is an extract derived from a South American edible plant cultivated at a very high altitude in the Andean mountain range since antiquity. The fruits are eaten raw or cooked and have been traditionally used by the indigenous population as a staple in their diet. Ethnobotanical usage of the fruit has been reported to improve the metabolic function (cholesterol and blood sugar reduction) and overall health of its consumers.
Recent scientific research in the form of several human clinical studies and investigations into Cycladol PS's mechanism of action and its unique biochemical composition has confirmed the extracts ability to significantly reduce the harmful LDL cholesterol and raise the cardioprotective "good" HDL cholesterol.
The molecular components of Cycladol PS reported to be responsible for its beneficial cholesterol lowering effects are specific flavon-glycosides known as triterpene saponins. These fruit-derived
compounds are thought to produce its favorable effect on cholesterol by the following mechanisms:
- The saponins form an insoluble complex with dietary cholesterol and prevent its absorption from the intestines.
- Saponins bind with bile in the intestines causing an increase in its fecal excretion and, thereby, indirectly lowering cholesterol (bile consists primarily of cholesterol and when its removed from the body more cholesterol has to be used to manufacture more bile)
- The glycosides are powerful antioxidants and protect the LDL cholesterol from harmful peroxidation. Peroxidation transforms the LDL cholesterol into artery-clogging plaque.
- Saponins also have blood sugar lowering effect (hypoglycemic) by slowing down the absorption of sugar and stabilizing the release of insulin.
In all of Cycladol PS's clinical studies, there have been no reported side effects or drug interactions. Cycladol PS is most effective when taken in the morning or on an empty stomach with 8 ounces of fluid.
The Journal of the North American Menopause Society: Vol. 2 No. 4, P 115-234
Serum Lipid and Lipoprotein Levels in Postmenopausal Women: Short-Course Effect of Caigua
Abstract: The present study was designed to determine lipid profiles in post-menopausal women, as well as the effect of short-term increasing oral doses of dehydrated natural caigua (Cycladin*) on serum cholesterol levels, low-density lipoprotein (LDL) cholesterol levels, high-density lipoprotein (HDL) cholesterol levels, and triglycerides levels during 12 weeks of treatment.
Eighteen premenopausal and twenty-four postmenopausal women were studied. The family and personal histories of dyslipidemia, hypertension and obesity were similar in pre and postmenopausal women as were body weight, body mass index (BMI), waist/hip ratios, and blood pressure. The postmenopausal women were shorter. Postmenopausal women had higher plasma cholesterol levels, higher LDL cholesterol levels, higher triglyceride levels, and lower HDL cholesterol levels than did the premenopausal women.
In postmenopausal women, six capsules daily of dehydrated caigua was the study's only dose that effectively reduced total serum cholesterol levels and LDL cholesterol levels and also significantly increased serum HDL cholesterol levels. At the end of the 12 weeks of treatment, serum cholesterol levels were 22% below pretreatment values and serum LDL cholesterol was 33% below initial values, whereas serum HDL cholesterol levels increased to >33% of initial values. Daily treatment with four capsules, two capsules, or placebo failed to modify lipid profiles effectively in postmenopausal women.
Treatment with six capsules of caigua daily during 12 weeks reduced the rate of hypercholesterolemia from 75% at the beginning of the study to 12.5% at the end of the treatment; similarly , it reduced the rate of hyper-LDL cholesterolemia from 75 to 12.5% and hypo-HDL cholesterolemia from 62.5 to 12.5%. Treatment with caigua had no effect on the prevalence of hypertriglyceridemia. We conclude that our patients with menopause had different lipid profiles from those of the premenopausal women. Menopause alters the lipid profile and treatment with caigua, a natural plant that is administered dehydrated and capsulated, can reverse dyslipidemia in the postmenopausal women.
The molecular components of Cycladol PS dietary supplement is a fruit-derived compound reported to be responsible for its beneficial cholesterol lowering effects that are specific flavon-glycosides known as triterpene saponins.
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Dietary supplements are not to be used to prevent or treat or cure any disease. The Statements in this website have not been evaluated by the FDA. Any information provided on this web site is not a substitute for the advice of a licensed medical practitioner. Individuals are advised not to self-medicate in the presence of significant illness. Ingredients in supplements are not drugs and may not be foods. CalComp Nutrition does not advise administration of supplements to infants or children and no supplements should be taken in pregnancy without professional advice.
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